TY - DATA T1 - Top genome-wide significant SNPs associated with bone mineral density of the total-body less head, lower limb, upper limb and skull. PY - 2014/06/19 AU - John P. Kemp AU - Carolina Medina-Gomez AU - Karol Estrada AU - Beate St Pourcain AU - Denise H. M. Heppe AU - Nicole M. Warrington AU - Ling Oei AU - Susan M. Ring AU - Claudia J. Kruithof AU - Nicholas J. Timpson AU - Lisa E. Wolber AU - Sjur Reppe AU - Kaare Gautvik AU - Elin Grundberg AU - Bing Ge AU - Bram van der Eerden AU - Jeroen van de Peppel AU - Matthew A. Hibbs AU - Cheryl L. Ackert-Bicknell AU - Kwangbom Choi AU - Daniel L. Koller AU - Michael J. Econs AU - Frances M. K. Williams AU - Tatiana Foroud AU - M. Carola Zillikens AU - Claes Ohlsson AU - Albert Hofman AU - André G. Uitterlinden AU - George Davey Smith AU - Vincent W. V. Jaddoe AU - Jonathan H. Tobias AU - Fernando Rivadeneira AU - David M. Evans UR - https://plos.figshare.com/articles/dataset/_Top_genome_wide_significant_SNPs_associated_with_bone_mineral_density_of_the_total_body_less_head_lower_limb_upper_limb_and_skull_/1062672 DO - 10.1371/journal.pgen.1004423.t002 L4 - https://ndownloader.figshare.com/files/1541069 KW - Biochemistry KW - metabolism KW - Bone and mineral metabolism KW - Computational biology KW - genome analysis KW - Genome-wide association studies KW - genetics KW - Human genetics KW - rheumatology KW - genome-wide KW - snps KW - total-body N2 - (TBLH-BMD) = total-body less head BMD, (LL-BMD) = lower limb BMD, (UL-BMD) = upper limb BMD, (SK-BMD) = skull BMD, (GENE) = closest gene, (POS) = position in the genome based on hg18, (EAF) = effect allele frequency, (β) = estimates of effect size expressed as adjusted SD per copy of the effect allele (EA), (SE) = standard error of β, (P) = pvalue, (I2) = Cochran's Q statistic evaluating heterogeneity, (PHET) = evidence of heterogeneity and*Sample sizes used for SK-BMD genome-wide meta-analysis.**Please note that PTHLH is also located at the 12p11.22 locus containing KLHDC5, RSPO3 is also located at the 6q.22.32 locus containing CENPW, FAM3C and CPED1 are also located at the 7q.31.31 locus containing WNT16, TNFRSF11B is also located at the 8q.24.12 locus containing COLEC10, LGR4 is also located at the 11p14.1 locus containing LIN7C and LRP5 is also located at the 11q13.2 locus containing PPP6R3. ER -