10.1371/journal.pone.0099593.g009 Laura Iop Laura Iop Antonella Bonetti Antonella Bonetti Filippo Naso Filippo Naso Stefania Rizzo Stefania Rizzo Stefano Cagnin Stefano Cagnin Roberto Bianco Roberto Bianco Carlo Dal Lin Carlo Dal Lin Paolo Martini Paolo Martini Helen Poser Helen Poser Paolo Franci Paolo Franci Gerolamo Lanfranchi Gerolamo Lanfranchi Roberto Busetto Roberto Busetto Michel Spina Michel Spina Cristina Basso Cristina Basso Maurizio Marchini Maurizio Marchini Alessandro Gandaglia Alessandro Gandaglia Fulvia Ortolani Fulvia Ortolani Gino Gerosa Gino Gerosa Gene expression profiles at 15 months post-implantation. Public Library of Science 2014 anatomy biological tissue Connective tissue Cardiovascular anatomy biotechnology Bioengineering Biomedical Engineering Tissue engineering biomaterials Medical devices and equipment cell biology Cellular structures and organelles Extracellular matrix Molecular cell biology cardiology Cardiovascular diseases Valvular diseases profiles 15 months 2014-06-18 03:55:57 Figure https://plos.figshare.com/articles/figure/_Gene_expression_profiles_at_15_months_post_implantation_/1061197 <p>Histograms representing enriched Gene Ontology terms for clusters 1, 3, 4 (green and red bars) and 2 (blue bars). P-value ≤0,05 (A). Gene interaction network derived from STRING database analysis of up- and down-regulated genes on A.L. tissues (clusters 1, 3, 4). Pink nodes with grey border connect elements between up- or down-regulated nodes in analyzed clusters. Central color node: gene expression in A.L. tissues; border: B.L. tissues. Yellow edges link connected nodes, while blue edges those altered in analyzed clusters. Purple gene names represent relevant nodes according to Centiscape algorithm. *Genes discussed in the text (B).</p>