TY - DATA T1 - Acid-Catalyzed Transacetalization from Glycol to Pinacol Acetals PY - 2014/08/25 AU - Yvonne Seeleib AU - Gregor Nemecek AU - Dominik Pfaff AU - Bastian D. Süveges AU - Joachim Podlech UR - https://tandf.figshare.com/articles/journal_contribution/Acid_Catalyzed_Transacetalization_from_Glycol_to_Pinacol_Acetals/1057874 DO - 10.6084/m9.figshare.1057874.v4 L4 - https://ndownloader.figshare.com/files/1535523 KW - acid-catalyzed KW - transacetalization KW - glycol KW - pinacol KW - acetals N2 - A one-pot transacetalization of glycol acetals, frequently used as protecting groups of the aldehyde function, into the more stable pinacol acetals is given. A clean transformation of aromatic and aliphatic substrates is possible with trifluoroacetic acid within 30 min at 0 °C. Glycol acetals derived from ketones (ketals) cannot be converted with this protocol. Deprotection of the pinacol acetals is possible with trifluoromethanesulfonic acid in the presence of water. ER -