Schematic presentation of Nef role. In-Woo Park Yan Fan Xiaoyu Luo Myoung-Gwi Ryou Jinfeng Liu Linden Green Johnny J. He 10.1371/journal.pone.0099545.g008 https://plos.figshare.com/articles/figure/_Schematic_presentation_of_Nef_role_/1051388 <p>The transferred Nef from HIV-1-infected cells to hepatocytes through conduits could exacerbate liver decay by enhancing HCV replication independently or together with ethanol and by producing ROS independently or synergistically with ethanol/HCV replication cycle. The dashed arrows indicate newly identified Nef role in hepatocytes.</p> 2014-06-09 03:37:55 Biochemistry metabolism Biological transport cell biology Cellular types Animal cells Blood cells White blood cells t cells Immune cells immunology Clinical immunology HIV immunopathogenesis microbiology Medical microbiology Microbial pathogens Viral pathogens Immunodeficiency viruses hiv Gastroenterology and hepatology Liver diseases Infectious hepatitis Hepatitis C Infectious diseases Viral diseases hepatitis nef