TY - DATA T1 - Phylogenetic Maximum Likelihood tree of the somatostatin receptor gene family PY - 2012/12/18 AU - Daniel Ocampo Daza AU - Görel Sundström AU - Christina A Bergqvist AU - Dan Larhammar UR - https://figshare.com/articles/figure/Phylogenetic_Maximum_Likelihood_tree_of_the_somatostatin_receptor_gene_family_/104690 DO - 10.6084/m9.figshare.104690.v2 L4 - https://ndownloader.figshare.com/files/3070340 KW - somatostatin receptors KW - phylogenetic tree KW - evolution KW - molecular evolution KW - Molecular Biology KW - Bioinformatics KW - Evolutionary Biology N2 - Published in: Ocampo Daza D, Sundström G, Bergqvist CA, Larhammar D. The evolution of vertebrate somatostatin receptors and their gene regions involves extensive chromosomal rearrangements. BMC Evolutionary Biology 2012, 12:231 doi:10.1186/1471-2148-12-231. Please refer to this article if using this figure. Figure 1 Phylogenetic Maximum Likelihood tree of the somatostatin receptor genefamily. The topology is supported by a non-parametric bootstrap test with 100 replicates aswell as an SH-like approximate likelihood ratio test (aLRT). The tree is rooted with thehuman kisspeptin receptor 1 sequence (not shown). Branch support (bootstrap replicates) fordeep divergences is shown at the nodes. All branch support values are shown in Figure S1(bootstrap replicates) and Figure S2 (aLRT) (see Additional file 2). The phylogenetic treeshows six well-supported subtype clusters, with the somatostatin receptor subtypes SSTR2, -3and -5 forming one ancestral branch and the SSTR1, -4 and -6 receptor subtypes forming oneancestral branch. This phylogenetic analysis supports the emergence of all six subtypes earlyin vertebrate evolution, with the subsequent loss of SSTR4 in ray-finned fishes, before thedivergence of the spotted gar and teleost lineages, and of SSTR6 in the tetrapod lineage. Allsix subtypes could be identified in the coelacanth genome. A seventh SSTR2-like sequence,called SSTRX in the tree, could also be identified on the same genomic scaffold in thecoelacanth genome (see Additional file 1, Supplemental note 1). There are well-supportedteleost-specific duplicate branches of SSTR2, -3 and -5, although all could not be identified inall teleost genomes. These duplicates have been named a and b based on the phylogeneticanalysis. There is a third SSTR3 sequence in the green puffer, called SSTR3c in the tree.   ER -