%0 Figure %A Pukkila-Worley, Read %A L. Feinbaum, Rhonda %A L. McEwan, Deborah %A Conery, Annie L. %A Ausubel, Frederick M. %D 2014 %T Protection from the toxic effects of the xenobiotic RPW-24 requires MDT-15, but not PMK-1. %U https://plos.figshare.com/articles/figure/_Protection_from_the_toxic_effects_of_the_xenobiotic_RPW_24_requires_MDT_15_but_not_PMK_1_/1040297 %R 10.1371/journal.ppat.1004143.g006 %2 https://ndownloader.figshare.com/files/1514142 %K immunology %K Immune system %K Innate immune system %K immunity %K microbiology %K organisms %K animals %K invertebrates %K nematoda %K caenorhabditis %K Caenorhabditis elegans %K Infectious diseases %K Bacterial diseases %K Pseudomonas infections %K Pathology and laboratory medicine %K pathogenesis %K Host-pathogen interactions %K Model organisms %K Animal models %K xenobiotic %K rpw-24 %K requires %X

(A) The thirteen xenobiotic detoxification genes that were induced 4-fold or greater by RPW-24 in the NanoString nCounter gene expression analysis are presented. The top panel compares the RPW-24-mediated induction of these genes in vector control (L4440) and mdt-15(RNAi) animals, and the bottom panel shows these data for wild-type N2 versus pmk-1(km25) animals, as described in the legend for Figure 2. * p<0.05 for the comparison of the RPW-24-induced conditions. (B) Vector control (L4440), mdt-15(RNAi) and pmk-1(RNAi) animals were exposed to 70 µM RPW-24 or the solvent control DMSO from the L1 stage and photographed after 70 hours of development at 20°C. See Figure S4 for the quantification data from this experiment.

%I PLOS Pathogens