TY - DATA T1 - Alterations detected in the K22 resistant variants of HCoV-229E. PY - 2014/05/29 AU - Anna Lundin AU - Ronald Dijkman AU - Tomas Bergström AU - Nina Kann AU - Beata Adamiak AU - Charles Hannoun AU - Eveline Kindler AU - Hulda R. Jónsdóttir AU - Doreen Muth AU - Joeri Kint AU - Maria Forlenza AU - Marcel A. Müller AU - Christian Drosten AU - Volker Thiel AU - Edward Trybala UR - https://plos.figshare.com/articles/dataset/_Alterations_detected_in_the_K22_resistant_variants_of_HCoV_229E_/1040292 DO - 10.1371/journal.ppat.1004166.t001 L4 - https://ndownloader.figshare.com/files/1514137 KW - Veterinary science KW - Veterinary diseases KW - Veterinary virology KW - Zoonoses KW - Infectious diseases KW - Viral diseases KW - Common cold KW - sars KW - Pulmonology KW - Respiratory infections KW - k22 KW - resistant KW - variants N2 - aDetected by comparison of the nucleotide sequences of HCoV-229E subjected to 10–13 passages in the presence of K22 including its plaque purified variants A-R with those of initial virus or mock-passaged virus (accession number KF293665).bPlaque purified HCoV-229E that served as initial material for the virus passages.cIC50 (µM).dFold resistance to K22 as related to initial virus is shown in parentheses.eVirus preparation and its plaque purified variants M-R obtained in separate K22 selection experiment.fThe virus used for preparation of recombinant nsp6 mutants.gK22 resistant recombinant viruses. ER -