Inducibility of DADs is decreased in cAF due to the stabilizing effect of remodeled I<sub>K1</sub>. Jussi T. Koivumäki Gunnar Seemann Mary M. Maleckar Pasi Tavi 10.1371/journal.pcbi.1003620.g007 https://plos.figshare.com/articles/figure/_Inducibility_of_DADs_is_decreased_in_cAF_due_to_the_stabilizing_effect_of_remodeled_I_K1_/1034698 <p>DADs were induced with either an extra Ca<sup>2+</sup> release from the junctional sarcoplasmic reticulum (A–C) or an extra current stimulus (D&E) at the time point of 1 second. Same protocol was used to study four model variants: normal sinus rhythm (nSR), chronic atrial fibrillation with all modifications (cAF: all), only modified inward rectified K<sup>+</sup> current (cAF: IK1), and only ryanodine receptor Ca<sup>2+</sup> sensitivity (cAF: RyR).</p> 2014-05-22 03:35:30 physics dads caf stabilizing remodeled