10.1371/journal.pone.0097359.g009
Chunfan Jiang
Chunfan
Jiang
Tao Huang
Tao
Huang
Yun Wang
Yun
Wang
Guowei Huang
Guowei
Huang
Xia Wan
Xia
Wan
Jiang Gu
Jiang
Gu
IgG expression was strongly correlated to MTA1 expression and IgG down-regulation lowered MTA1 expression.
Public Library of Science
2014
Biochemistry
proteins
Immune system proteins
antibodies
cell biology
Cell processes
Cell growth
Molecular cell biology
genetics
gene expression
immunology
Clinical immunology
immunopathology
oncology
Basic cancer research
metastasis
Cancers and neoplasms
carcinomas
adenocarcinomas
Adenocarcinoma of the lung
Squamous cell carcinomas
Squamous cell lung carcinoma
Lung and intrathoracic tumors
Cancer detection and diagnosis
Pathology and laboratory medicine
Clinical pathology
correlated
mta1
igg
down-regulation
lowered
2014-05-22 03:31:30
Figure
https://plos.figshare.com/articles/figure/_IgG_expression_was_strongly_correlated_to_MTA1_expression_and_IgG_down_regulation_lowered_MTA1_expression_/1034681
<p><b>A</b>, IgG was down-regulated with specific IGHG1 siRNA transfection with Real-time PCR. <b>B</b>, MTA1 expression was lowered following the decrease of IgG expression detected with Real-time PCR. <b>C</b>, typical bands represent the changes of IgG and MTA1 expressions after IGHG1 siRNA interference in A549 cell line. <b>D</b>, similar changes in SK-MES-1 cell line. <b>E</b>, Igγ (red, positive staining in cytoplasm) was mostly co-localized with MTA1 (purplish red, positive staining in nuclei) in lung cancers. Black arrows or arrowheads show typical cancer cells labeling with IgG and MTA1. <b>F</b>, lung cancers with weak IgG expression have a lower expression level of MTA1 in comparison to strong IgG expression cancers. <b>G</b>, lung cancers with lymph node metastasis have much higher MTA1 expression than non-metastatic cancers. The histograms represent the four independent assays. Data are presented as mean ± S.E. *, <i>p</i><0.05. Scale bars: 20 µm.</p>