Ma, Jin J. Chadban, Steven Y. Zhao, Cathy Chen, Xiaochen Kwan, Tony Panchapakesan, Usha Pollock, Carol A. Wu, Huiling High concentration glucose induces inflammation in TECs via TLR4. <p>Primary cultures of TECs, harvested from WT and TLR4<sup>−/−</sup> mice, were cultured in media containing physiological concentration glucose (5.5 mM glucose+24.5 mM mannitol) as an osmotic control or high-concentration glucose (5.5 mM glucose+24.5 mM glucose) for 12 hours. High glucose induced upregulation of TLR4 (A), its ligands (B) and downstream molecules(C) in WT TECs compared to osmotic controls. Upregulation of downstream molecules induced by high-glucose was not seen in TLR4<sup>−/−</sup> TECs (C). Data are presented as means ± SEM; * <i>p</i><0.05; ** <i>p</i><0.01; *** <i>p</i><0.001.</p> cell biology;Signal transduction;cell signaling;Membrane receptor signaling;Immune receptor signaling;Immunological signaling;Molecular cell biology;Metabolic disorders;Diabetes mellitus;Type 1 diabetes;type 2 diabetes;Nephrology;Chronic kidney disease;Model organisms;Animal models;Mouse models;glucose;inflammation;tecs 2014-05-19
    https://plos.figshare.com/articles/figure/_High_concentration_glucose_induces_inflammation_in_TECs_via_TLR4_/1031194
10.1371/journal.pone.0097985.g009