TY - DATA T1 - UR domains are heterochromatic. PY - 2014/05/01 AU - Roberta L. Hannibal AU - Edward B. Chuong AU - Juan Carlos Rivera-Mulia AU - David M. Gilbert AU - Anton Valouev AU - Julie C. Baker UR - https://plos.figshare.com/articles/figure/_UR_domains_are_heterochromatic_/1013499 DO - 10.1371/journal.pgen.1004290.g005 L4 - https://ndownloader.figshare.com/files/1481541 KW - cell biology KW - Chromosome biology KW - chromosomes KW - Chromosome structure and function KW - chromatin KW - developmental biology KW - Cell differentiation KW - genetics KW - epigenetics KW - Histone modification KW - genomics KW - Structural genomics KW - gene expression KW - domains N2 - A. UR domains correlate with histone marks. Screen shot from the UCSC genome browser of the last half of chromosome 14 (schematic shown above screen shot) showing the following: 3SEQ from in vivo e9.5 TGCs and in vitro d7 TGCs (black), active histone marks (H3K27ac, H3K4me1, H3K4me3; dark purple) and repressive histone marks (H3K9me3, H3K27me3; orange) for cultured TS cells and TGCs, and aCGH and WGS data from in vivo e9.5 TGCs (pink/red). Histone mark mean is darker color, maximum is lighter color. UR domains boxed in pink. B. UR domains are a subset of heterochromatin in TS cells. The Pearson correlation (R) between NLog2 values of TGC vs. embryo (WGS) and fold enrichment (FE) for histone marks. Data points represent 1 Mb windows in the genome. UR domains (negative NLog2 values) are correlated with high values for repressive histone marks (negative R values). UR domains (negative NLog2 values) are negatively correlated with high values for active histone marks (positive R values). Red lines represent the lowess line (locally weighted scatterplot smoothing) of the data points. UR domains boxed in pink. C. UR domains are a subset of heterochromatin in TGCs. See (B) for plot details. ER -