10.1371/journal.pone.0095243.g004
Fei Yan
Fei
Yan
Yang Yu
Yang
Yu
Dar-Chone Chow
Dar-Chone
Chow
Timothy Palzkill
Timothy
Palzkill
Franck Madoux
Franck
Madoux
Peter Hodder
Peter
Hodder
Peter Chase
Peter
Chase
Patrick R. Griffin
Patrick R.
Griffin
Bert W. O'Malley
Bert
W. O'Malley
David M. Lonard
David
M. Lonard
Verrucarin A inhibits SRC-3 downstream target gene (MMP2 and MMP13) expression.
Public Library of Science
2014
Biochemistry
enzymology
Enzyme chemistry
Cofactors (biochemistry)
chemical biology
biotechnology
Small molecules
oncology
Cancer treatment
pharmacology
Drug research and development
drug discovery
inhibits
src-3
downstream
2014-04-17 04:12:05
Figure
https://plos.figshare.com/articles/figure/_Verrucarin_A_inhibits_SRC_3_downstream_target_gene_MMP2_and_MMP13_expression_/1003559
<p>(A–B) Luciferase assays were performed in HeLa cells transiently transfected with MMP2-Luc, MMP13-Luc, and pCR3.1-SRC-3 expression vectors before incubation with verrucarin A at different concentrations (0, 2, 5, and 10 nM) for 24 h. (C) H1299 cells were treated with verrucarin A at different concentrations (0, 10, and 20 nM) for 24 h, then real-time PCR was performed to quantitate SRC-1, SRC-2, SRC-3, MMP2, and MMP13 mRNA expression.</p>