1-Trifluoromethyl Epoxy Ethers. Effect of Hexafluoro-2-propanol on Reactions with Secondary Aromatic Amines: Synthesis of 3-Trifluoromethyl Indole Derivatives
2001-02-23T00:00:00Z (GMT) by
Trifluoromethyl epoxy ethers <b>1</b> and <b>2</b> reacted with aromatic amines in hexafluoro-2-propanol at room temperature providing trifluoromethyl indolinols <b>3 </b>and <b>4</b> in excellent isolated yields. 3-Trifluoromethyl indoles <b>9</b> and <b>10</b> could be prepared by treatment of indolinols with SOCl<sub>2</sub>.