shRAC2 from "Mitochondrial dysfunction in human leukemic stem/progenitor cells upon loss of RAC2"

BCR-ABL and shRNA double-transduced cells expanded in stromal co-cultures for 7 days were harvested, pelleted and embedded in EPON, and ultrathin sections were analyzed by STEM. Large area scans of high resolution were acquired allowing evaluation of the ultrastructure of mitochondria in large number of control cells or shRAC2-transduced cells, representative images of the abnormalities in the structure of mitochondria are shown.10 nm pixel size screenshots from www.nanotomy.org.