[3 + 2] Cycloaddition Reaction of in Situ Formed Azaoxyallyl
Cations with Aldehydes: An Approach to Oxazolidin-4-ones

Lin, Aijun

[3 + 2] Cycloaddition Reaction of in Situ Formed Azaoxyallyl Cations with Aldehydes: An Approach to Oxazolidin-4-ones

Version 2 2016-09-12, 20:23

Version 1 2016-08-27, 12:13

Posted on 2016-08-29 - 00:00

A novel [3 + 2] cycloaddition reaction between in situ formed azaoxyallyl cations and aldehydes has been developed. This concise method allows the rapid formation of a number of oxazolidin-4-ones in high yields with good functional group tolerance at room temperature. Further transformation and late-stage modifications of drug molecules could also be achieved in good yields, highlighting the potential utility of the reaction.

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Zhang, Kaifan; Yang, Chi; Yao, Hequan; Lin, Aijun (2016). [3 + 2] Cycloaddition Reaction of in Situ Formed Azaoxyallyl Cations with Aldehydes: An Approach to Oxazolidin-4-ones. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.6b02254

https://doi.org/10.1021/acs.orglett.6b02254

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