Supplementary material from "Early evolution of radial glial cells in Bilateria"
Posted on 2017-06-27 - 14:53
Bilaterians usually possess a central nervous system, composed of neurons and supportive cells called glial cells. Whereas neuronal cells are highly comparable in all these animals, glial cells apparently differ and in deuterostomes, radial glial cells are found. These particular secretory glial cells may represent the archetype of all (macro) glial cells and were not reported from protostomes so far. This has caused controversial discussions of whether glial cells represent a homologous bilaterian characteristic or whether they (and thus, centralized nervous systems) evolved convergently in the two main clades of bilaterians. By using histology, transmission electron microscopy, immunolabelling and whole-mount in situ hybridization, we show here that protostomes also possess radial glia-like cells, which are very likely homologous to those of deuterostomes. Moreover, our antibody staining indicates that the secretory character of radial glial cells is maintained throughout their various evolutionary adaptations. This implies an early evolution of radial glial cells in the last common ancestor of Protostomia and Deuterostomia. Furthermore, it suggests that an intraepidermal nervous system—composed of sensory cells, neurons and radial glial cells—was likely the plesiomorphic condition in the bilaterian ancestor.
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Helm, Conrad; Karl, Anett; Beckers, Patrick; Kaul-Strehlow, Sabrina; Ulbricht, Elke; Kourtesis, Ioannis; et al. (2017). Supplementary material from "Early evolution of radial glial cells in Bilateria". The Royal Society. Collection. https://doi.org/10.6084/m9.figshare.c.3811681.v1
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AUTHORS (11)
CH
Conrad Helm
AK
Anett Karl
PB
Patrick Beckers
SK
Sabrina Kaul-Strehlow
EU
Elke Ulbricht
IK
Ioannis Kourtesis
HK
Heidrun Kuhrt
HH
Harald Hausen
TB
Thomas Bartolomaeus
AR
Andreas Reichenbach
CB
Christoph Bleidorn