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Michael Hunsaker

0000-0001-9210-2458

Postdoctoral Scholar (Behavioural neuroscience)

Salt Lake City, UT

My research has been focused on the development of behavioral paradigms designed to specifically test different attributes or domains of memory function, with an emphasis on spatial and temporal information processing. In 2008, my emphasis moved from evaluating the role of hippocampal subregions for spatial and temporal memory in rats to behaviorally evaluating mouse models of neurodevelopmental and neurodegenerative genetic disease. With mouse models of genetic disease, my focus has been to design behavioral paradigms and collections/batteries of behavioral assays to comprise behavioral endophenotypes, or quantitative patterns of behavioral strengths and weaknesses that scale with the dosage of the genetic mutation. My research priority is to develop novel behavioral paradigms that directly model the cognitive paradigms used in the clinic to evaluate patient populations

Publications

  • http://whyhaventtheydonethatyet.squarespace.com/publications/
  • Evaluation of metric, topological, and temporal ordering memory tasks after lateral fluid percussion injury DOI: 10.1089/neu.2012.2463
  • The medial and lateral entorhinal cortex both contribute to contextual and item recognition memory: A test of the binding ofitems and context model DOI: 10.1002/hipo.22097
  • The operation of pattern separation and pattern completion processes associated with different attributes or domains of memory DOI: 10.1016/j.neubiorev.2012.09.014
  • Abnormal dendrite and spine morphology in primary visual cortex in the CGG knock-in mouse model of the fragile X premutation DOI: 10.1111/j.1528-1167.2012.03486.x
  • CGG trinucleotide repeat length modulates neural plasticity and spatiotemporal processing in a mouse model of the fragile X premutation DOI: 10.1002/hipo.22043
  • Comprehensive neurocognitive endophenotyping strategies for mouse models of genetic disorders DOI: 10.1016/j.pneurobio.2011.12.001
  • Distribution and frequency of intranuclear inclusions in female CGG KI mice modeling the fragile X premutation DOI: 10.1016/j.brainres.2012.06.052
  • Female CGG knock-in mice modeling the fragile X premutation are impaired on a skilled forelimb reaching task DOI: 10.1016/j.nlm.2011.12.006
  • Mouse models of the fragile X premutation and the fragile X associated tremor/ataxia syndrome DOI: 10.1007/978-3-642-21649-7_14
  • Neuropathological, clinical and molecular pathology in female fragile X premutation carriers with and without FXTAS DOI: 10.1111/j.1601-183X.2012.00779.x
  • Spatiotemporal processing deficits in female CGG KI mice modeling the fragile X premutation DOI: 10.1016/j.bbr.2012.04.029
  • The importance of considering all attributes of memory in behavioral endophenotyping of mouse models of genetic disease DOI: 10.1037/a0028453
  • Motor deficits on a ladder rung task in male and female adolescent and adult CGG knock-in mice DOI: 10.1016/j.bbr.2011.03.039
  • Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome DOI: 10.1186/2040-2392-2-2
  • Rare intranuclear inclusions in the brains of 3 older adult males with fragile X syndrome: Implications for the spectrum of fragile X-associated disorders DOI: 10.1097/NEN.0b013e31821d3194
  • The role of the dorsal and ventral hippocampus in olfactory working memory DOI: 10.1016/j.nlm.2011.06.011
  • Widespread non-central nervous system organ pathology in fragile X premutation carriers with fragile X-associated tremor/ataxia syndrome and CGG knock-in mice DOI: 10.1007/s00401-011-0860-9
  • Temporal ordering deficits in female CGG KI mice heterozygous for the fragile X premutation DOI: 10.1016/j.bbr.2010.05.010
  • The role of the dorsal CA1 and ventral CA1 in memory for the temporal order of a sequence of odors DOI: 10.1016/j.nlm.2009.08.010
  • The temporal attributes of episodic memory DOI: 10.1016/j.bbr.2009.12.029
  • Ubiquitin-positive intranuclear inclusions in neuronal and glial cells in a mouse model of the fragile X premutation DOI: 10.1016/j.brainres.2009.12.077
  • A Behavioral Analysis of the Role of CA3 and CA1 Subcortical Efferents During Classical Fear Conditioning DOI: 10.1037/a0015455
  • Progressive Spatial Processing Deficits in a Mouse Model of the Fragile X Premutation DOI: 10.1037/a0017616
  • Transecting the dorsal fornix results in novelty detection but not temporal ordering deficits in rats DOI: 10.1016/j.bbr.2009.02.012
  • A double dissociation of subcortical hippocampal efferents for encoding and consolidation/retrieval of spatial information DOI: 10.1002/hipo.20429
  • Chapter 1.5 The attributes of episodic memory processing DOI: 10.1016/S1569-7339(08)00205-1
  • Dissociating the Roles of Dorsal and Ventral CA1 for the Temporal Processing of Spatial Locations, Visual Objects, and Odors DOI: 10.1037/0735-7044.122.3.643
  • Dissociations across the dorsal-ventral axis of CA3 and CA1 for encoding and retrieval of contextual and auditory-cued fear DOI: 10.1016/j.nlm.2007.08.016
  • Evaluating the differential roles of the dorsal dentate gyrus, dorsal CA3, and dorsal CA1 during a temporal ordering for spatial locations task DOI: 10.1002/hipo.20455
  • Evaluating the temporal context of episodic memory: The role of CA3 and CA1 DOI: 10.1016/j.bbr.2007.11.015
  • Human topological task adapted for rats: Spatial information processes of the parietal cortex DOI: 10.1016/j.nlm.2008.05.002
  • The CA3 Subregion of the Hippocampus Is Critical for Episodic Memory Processing by Means of Relational Encoding in Rats DOI: 10.1037/a0013592
  • The Interactions and Dissociations of the Dorsal Hippocampus Subregions: How the Dentate Gyrus, CA3, and CA1 Process Spatial Information DOI: 10.1037/0735-7044.122.1.16
  • The role of the dentate gyrus, CA3a,b, and CA3c for detecting spatial and environmental novelty DOI: 10.1002/hipo.20464
  • Behavioral characterization of a transection of dorsal CA3 subcortical efferents: Comparison with scopolamine and physostigmine infusions into dorsal CA3 DOI: 10.1016/j.nlm.2007.01.006
  • Dissociations of the Medial and Lateral Perforant Path Projections Into Dorsal DG, CA3, and CA1 for Spatial and Nonspatial (Visual Object) Information Processing DOI: 10.1037/0735-7044.121.4.742
  • Role of dCA3 efferents via the fimbria in the acquisition of a delay nonmatch to place task DOI: 10.1002/hipo.20288
  • Disconnection analysis of CA3 and DG in mediating encoding but not retrieval in a spatial maze learning task DOI: 10.1101/lm.246906
  • Effects of ventral and dorsal CA1 subregional lesions on trace fear conditioning DOI: 10.1016/j.nlm.2006.01.002
  • The role of CA3 and CA1 in the acquisition of an object-trace-place paired-associate task DOI: 10.1037/0735-7044.120.6.1252
  • Dissociating the role of the parietal cortex and dorsal hippocampus for spatial information processing DOI: 10.1037/0735-7044.119.5.1307
  • The role of CA1 in the acquisition of an object-trace-odor paired associate task DOI: 10.1037/0735-7044.119.3.781
  • The role of hippocampal subregions in detecting spatial novelty DOI: 10.1037/0735-7044.119.1.145

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