Figure 4.TIF (743.56 kB)
Variation of tolerance associated with HLA-B genotype.
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posted on 2014-09-16, 03:14 authored by Roland R. Regoes, Paul J. McLaren, Manuel Battegay, Enos Bernasconi, Alexandra Calmy, Huldrych F. Günthard, Matthias Hoffmann, Andri Rauch, Amalio Telenti, Jacques Fellay(A) Frequencies of the HLA-B genotypes in our study population of 923 individuals. Approximately half of the genotypes are represented by only one individual. (B) Visualizing the random effect of the mixed effect modeling approach. Estimated tolerance curves for each HLA-B genotype, based on best linear unbiased predictions, are shown. We estimated a mean tolerance parameter (red curve), and a deviation of the random effects, , of (see Text S1).
