Signature of cofactors associated with the enrichment of a specific cardinal motif.

(A) Heatmap analysis of relative enrichment of cardinal motifs in proximal promoter regions occupied by different proteins, based on >60 ChIP-seq datasets: n = 8 TF ChIP-seq datasets (labeled in red) and n = 59 cofactors/others ChIP-seq datasets (labeled in black). Sources of ChIP-seq experiments: ENCODE (accession number and/or laboratory are included in parenthesis); and NRF1, NFYB, and LSD1 datasets were generated in this study. The vector of motif enrichment for each experiment was normalized and centered on the mean value to reveal the preferences of each experiment for cardinal motifs. The analysis shows negative log of the hypergeometric p-value. (B) List of cofactors associated with each cardinal motif, based on (A). (C) Model of signatures of cofactors associated with the presence of a specific cardinal motif (see text for details).