Figure_3.tif (251.99 kB)
MIV-150 local and systemic levels after vaginal and rectal application.
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posted on 2014-04-16, 04:16 authored by Larisa Kizima, Aixa Rodríguez, Jessica Kenney, Nina Derby, Olga Mizenina, Radhika Menon, Samantha Seidor, Shimin Zhang, Keith Levendosky, Ninochka Jean-Pierre, Pavel Pugach, Guillermo Villegas, Brian E. Ford, Agegnehu Gettie, James Blanchard, Michael Piatak Jr, Jeffrey D. Lifson, Gabriela Paglini, Natalia Teleshova, Thomas M. Zydowsky, Melissa Robbiani, José A. Fernández-RomeroMacaques were treated vaginally with MZC daily for 2 wks or once rectally. A) MIV-150 was measured by LCMS/MS in the plasma of vaginally (n = 6, filled circles) and rectally (n = 6, filled squares) treated macaques at various time points after the last gel application. B) Tissue biopsies (n = 12 per time point/type of tissue) and C) swabs (n = 6 per condition) were collected at the indicated times following the last gel and MIV-150 was measured (by LCMS/MS for tissues and RIA for swabs). The mean (± SD) concentrations of MIV-150 for each treatment group are shown (rectal, R; vaginal, V; cervical, C).
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microbiologyMedical microbiologyMicrobial pathogensViral pathogensImmunodeficiency viruseshivMicrobial controlantimicrobialsantiviralsAnimal models of infectionVirologyorganismsanimalsvertebratesmammalsprimatesmonkeysOld World monkeysmacaqueInfectious diseasesInfectious disease controlSexually transmitted diseasesViral diseasesPublic and occupational healthpreventive medicineHIV preventionModel organismsAnimal modelsMouse modelssystemicvaginalrectal
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