figshare
Browse
Figure_1.tif (145.39 kB)

Characterisation of FITC-N/OFQ (F-N/OFQ) at recombinant NOP and classical opioid receptors on CHO cells.

Download (0 kB)
figure
posted on 2013-09-23, 01:43 authored by Zoë L. S. Brookes, Emily N. Stedman, Nicola J. Brown, Christopher P. Hebbes, Remo Guerrini, Girolamo Calo, Charles S. Reilly, David G. Lambert

A: Binding affinity of F-N/OFQ and a range of opioid receptor subtype selective reference compounds. F-N/OFQ shows high selectivity for NOP over classical opioid receptors (mean (range) of up to 4 experiments.) *curves did not saturate Ki estimated between 1 and 10µM. B: Both N/OFQ and F-N/OFQ behave as full agonists on recombinant human NOP. These data are stimulation factor = agonist stimulated specific binding / basal specific binding (mean +SEM, n=8).

History

Usage metrics

    PLOS ONE

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC