ol6b02254_si_001.pdf (4.33 MB)
[3 + 2] Cycloaddition Reaction of in Situ Formed Azaoxyallyl Cations with Aldehydes: An Approach to Oxazolidin-4-ones
journal contribution
posted on 2016-08-27, 12:13 authored by Kaifan Zhang, Chi Yang, Hequan Yao, Aijun LinA novel [3 + 2] cycloaddition reaction
between in situ formed azaoxyallyl
cations and aldehydes has been developed. This concise method allows
the rapid formation of a number of oxazolidin-4-ones in high yields
with good functional group tolerance at room temperature. Further
transformation and late-stage modifications of drug molecules could
also be achieved in good yields, highlighting the potential utility
of the reaction.