Ultrasound-Promoted Environmentally Friendly Synthesis of 5-(3,3,3-Trifluoro-2-oxopropylidene)pyrrolidin-2-ones

S. F. Franco, Márcia; Casagrande, Gleison A.; Raminelli, Cristiano; Moura, Sidnei; Rossatto, Marcelo; Quina, Frank H.; M. P. Pereira, Claudio; F. C. Flores, Alex; Pizzuti, Lucas

doi:10.6084/m9.figshare.1243711.v4

lsyc_a_978504_sm4664.pdf (3.92 MB)

Ultrasound-Promoted Environmentally Friendly Synthesis of 5-(3,3,3-Trifluoro-2-oxopropylidene)pyrrolidin-2-ones

Version 4 2015-02-04, 15:03

Version 3 2015-02-04, 15:03

Version 2 2015-01-24, 06:43

Version 1 2015-02-04, 15:03

journal contribution

posted on 2015-02-04, 15:03 authored by Márcia S. F. Franco, Gleison A. Casagrande, Cristiano Raminelli, Sidnei Moura, Marcelo Rossatto, Frank H. Quina, Claudio M. P. Pereira, Alex F. C. Flores, Lucas Pizzuti

A facile, one-pot, ultrasound-promoted synthesis of N-substituted 5-(3,3,3-trifluoro-2-oxopropylidene)pyrrolidin-2-ones from methyl 7,7,7-trifluoro-4-methoxy-6-oxohept-4-enoate and a wide range of primary alkyl(aryl)amines using ethanol as a green solvent and employing triethylamine as a base is described.