lsyc_a_947653_sm3111.pdf (4.67 MB)
Synthesis of the Southern Tripeptide (C1–N12) of Sanglifehrins Using Asymmetric Organocatalysis
Version 4 2014-10-21, 00:39
Version 3 2014-10-21, 00:39
Version 2 2014-10-17, 21:59
Version 1 2014-10-21, 00:39
journal contribution
posted on 2014-10-21, 00:39 authored by Laghuvarapu Radhika, Srivari ChandrasekharThe tripeptide southern region of the novel cyclophilin binding natural product macrolides, namely sanglifehrins, is synthesized involving asymmetric organocatalysis as chirality-inducing step. List's asymmetric α-amination was used in the synthesis of the m-hydroxyphenylalanine part, whereas α-hydrazination was used for the piperazic ester part.