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Synthesis of a novel water-soluble conjugated polyelectrolyte based on polycyclopentadithiophene backbone and its application for heparin detection

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Version 3 2014-07-04, 13:54
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journal contribution
posted on 2014-07-04, 13:53 authored by Xiangwei Zhu, Wenjuan Guo, Huizhi Li, Guangyou Zhang, Meishan Pei, Luyan Wang, Jijun Feng

The novel water-soluble conjugated polyelectrolyte containing a new kind of backbone poly[(4,4-bis(3ʹ-N,N,N-trimethylammonium) propyl) cyclopentadithiophene dichloride] (PBTPC-Cl) is synthesized and characterized. The PBTPC-Cl is readily soluble in polar solvents and is applied as a sensitive and selective fluorescent probe for heparin detection in aqueous solution. Upon adding heparin into the aqueous solution of polymer, PBTPC-Cl could bind heparin via electrostatic interactions and results in the quenching of emission peaks. Quantitative analysis of heparin shows high selectivity and good linear relationship with a detection limit to 0.05 μM in HEPES aqueous buffer.

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