Synthesis and Evaluation of Coumarin–Resveratrol Hybrids as 15-Lipoxygenaze Inhibitors

Rahmani-Nezhad, Samira; Khosravani, Leila; Saeedi, Mina; Divsalar, Kouros; Firoozpour, Loghman; Pourshojaei, Yaghoub; Sarrafi, Yaghoub; Nadri, Hamid; Moradi, Alireza; Mahdavi, Mohammad; Shafiee, Abbas; Foroumadi, Alireza

doi:10.6084/m9.figshare.1235529.v4

lsyc_a_979947_sm5255.pdf (3.05 MB)

Synthesis and Evaluation of Coumarin–Resveratrol Hybrids as 15-Lipoxygenaze Inhibitors

Version 4 2015-02-04, 15:03

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Version 2 2015-01-24, 06:43

Version 1 2015-02-04, 15:03

journal contribution

posted on 2015-02-04, 15:03 authored by Samira Rahmani-Nezhad, Leila Khosravani, Mina Saeedi, Kouros Divsalar, Loghman Firoozpour, Yaghoub Pourshojaei, Yaghoub Sarrafi, Hamid Nadri, Alireza Moradi, Mohammad Mahdavi, Abbas Shafiee, Alireza Foroumadi

A series of coumarin–resveratrol hybrids, 3-arylcoumarin derivatives 3a–u, were synthesized through the intermolecular condensation reaction of various salicylaldehydes and phenylacetic acids in the presence of 1,4-diazabicyclo[2.2.2]octane under solvent-free conditions. All the synthesized compounds were screened for their inhibitory potency against soybean 15-lipoxygenase. Among them, three compounds (3c, 3j, and 3q) showed good enzyme-inhibitory activities.