figshare
Browse
gnpl_a_948436_sm6347.doc (144 kB)

Structure and hypolipidaemic activity of fucoidan extracted from brown seaweed Sargassum henslowianum

Download (0 kB)
Version 2 2015-01-08, 11:19
Version 1 2015-01-08, 11:19
journal contribution
posted on 2015-01-08, 11:19 authored by Ho Duc Cuong, Thanh Thi Thu Thuy, Tran Thu Huong, Bui Minh Ly, Tran Thi Thanh Van

The aim of this study is to elucidate the structure and investigate the hypolipidaemic activity of a fucoidan extracted from brown seaweed Sargassum henslowianum collected at Hai Van–Son Cha peninsula, Hue province, Vietnam by using tandem electrospray ionisation mass spectrometry. The results demonstrated that the fucoidan has α(1 → 3)-linked l-fucopyranose backbone and sulphate groups occupied mostly at C-2, C-4 and sometimes at C-3 position of fucose residues. The results of in vivo bioactivity examination revealed that the fucoidan in the dose of 100 mg/kgP/day by oral administration helped decrease cholesterol, triglyceride and LDL-cholesterol levels on obese mice.

History