gnpl_a_997231_sm1491.docx (90.76 kB)
Pistagremic acid, a novel β-secretase enzyme (BACE1) inhibitor from Pistacia integerrima Stewart
Version 2 2015-08-04, 14:27
Version 1 2015-08-04, 14:27
journal contribution
posted on 2015-08-04, 14:27 authored by Abdur Rauf, Ghias Uddin, Ajmal Khan, Bina S. Siddiqui, Mohammad Arfan, Kourosh Dalvandi, Taibi Ben HaddaA new triterpenic compound named pistagremic acid (PA) was once again isolated from Pistaciaintegerrima. The β-secretase inhibition study was carried out. Compound PA was found significantly active against β-secretase enzyme (BACE1) with IC50 value of 350 ± 2 nM in comparison to the standard inhibitors [Asn670, Sta671, Val672]-amyloid-β/A4 precursor protein 770 fragment 662–675 (IC50 = 290.71 ± 1 nM). The selectivity of this compound was also evaluated against the acetylcholinesterase and butyrylcholinesterase enzymes. Interestingly compound PA was found to be inactive against them and showed selectivity towards β-secretase enzyme (BACE1).