PCR-based alternative for diagnosis of immunoglobulin heavy chain gene rearrangement: principles, practice, and polemics

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Diaz-Cano, Salvador J. (2012): PCR-based alternative for diagnosis of immunoglobulin heavy chain gene rearrangement: principles, practice, and polemics. figshare.
http://dx.doi.org/10.6084/m9.figshare.97678
Retrieved 09:15, Jul 22, 2014 (GMT)

Description

PCR-based detection of immunoglobulin gene rearrangements is a reliable and accurate method which can be utilized as a clinical test if appropriate quality controls are performed (internal, polyclonal and monoclonal, sensitivity and specificity controls) and strict criteria for clonal rearrangements are used to exclude false-positives and false-negatives.

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