On evaluating the accuracy and biological plausibility of diffusion MRI tractograms

One of the major limitations of diffusion MRI tractography is that the tractograms, i.e. set of fiber tracts, recovered by existing algorithms are not truly quantitative. 

A number of methods have recently started to appear to address this limitation; in particular, COMMIT and LiFE have been developed upon the recently proposed framework that showed how to formulate tractography as an efficient system of linear equations, opening de facto the door for the practical possibility to evaluate and compare the accuracy of the tractograms.

This work investigates the importance of using (i) proper multi-compartment models and (ii) adequate multiple b-value acquisitions in order to be able to evaluate the accuracy and the biological plausibility of the tractograms using these global approaches.