chaos.001.tiff (6.73 MB)

Nonlinear models (chaos theory)

figure

posted on 2014-07-08, 17:06 authored by Jorge H RamirezJorge H Ramirez, Lorena Franco

Just an image (version 1) that represents some variables that influence the effect of drugs from low to high levels of complexity.

1. Low levels of complexity: drug-receptor interactions (e.g., study of receptor theories explaining the pharmacological effects of drugs).

2. High levels of complexity: Society (e.g., pharmacoeconomics, health-care systems, drug adherence in real-life settings outside trials).

There are excellent papers related to the study of chaos theory in biological systems. 1-4

References

1. Firth W J. Chaos--predicting the unpredictable. BMJ 1991; 303:1565.

2. Lipsitz LA, Goldberger AL. Loss of 'Complexity' and Aging: Potential Applications of Fractals and Chaos Theory to Senescence. JAMA. 1992;267(13):1806-1809. doi:10.1001/jama.1992.03480130122036.

3. Goldberger, A. L. (1990). Chaos and fractals in human physiology. Scientific American, 262(2), 42-49.

4. T. Elbert, W. J. Ray, Z. J. Kowalik, J. E. Skinner, K. E. Graf, and N. Birbaumer. Chaos and physiology: deterministic chaos in excitable cell assemblies
Physiol Rev January 1, 1994 74:(1) 1-47