figshare
Browse
gnpl_a_895725_sm8052.docx (2.98 MB)

New ceramide from the aerial part of Tinospora oblongifolia with cytotoxic activities

Download (0 kB)
Version 2 2014-04-23, 07:27
Version 1 2014-04-23, 07:27
journal contribution
posted on 2014-04-23, 07:27 authored by Fidelis Samita, Charles O. Ochieng, Philip O. Owuor, Lawrence A.O. Manguro

A new ceramide, 2,3-dihydroxy-N-[(2S,3S,4R)-1,3,4-trihydroxyicosan-2-yl[tetracosanamide (1) along with four known compounds: 2-(4′-hydroxyphenyl)-ethyl lignocerate (2), docosyl-3,4-dihydroxy-trans-cinnamate (3), β-sitosterol (4) and β-sitosterol glycoside (5) were isolated from Tinospora oblongifolia (Menispermaceae). Their structures were determined on the basis of spectroscopic methods, mass spectrometry analysis as well as chemical transformation and by comparing their physical and spectral data with those reported in the literature. Compound 1 exhibited strong cytotoxic activity against KB cells with IC50 = 3.4 μM although less than that of camptothecin IC50 = 0.3 μM (positive control).

History

Usage metrics

    Natural Product Research

    Categories

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC