Influence of intratumour heterogeneity in the interpretation of marker results in phaeochromocytomas
Description
Krijger et al.1 try to predict the clinical behaviour of a phaeochromocytomas (PCCs) on the basis of the immunoreactivity of three markers (p53, bcl-2, and c-erbB-2). They conclude that the co-expression of p53 and bcl-2 proteins may assist that prediction. Our own preliminary results2,3 mainly agree with theirs and point towards two interrelated biological issues: firstly, the clonal evolution of neo- plasms and intratumour heterogeneity of markers; and secondly, the importance of apoptosis in tumour initiation and progression.
Krijger et al. clearly indicate the importance of p53 and bcl-2 in the pathogenesis of a subgroup of PCCs. However, the variability of marker expression and the potential relationship with kinetic features are also helpful in understanding the pathogenesis of PCC.
Links
- https://www.researchgate.net/publication/12683917_Influence_of_intratumour_heterogeneity_in_the_interpretation_of_marker_results_in_phaeochromocytomas
- http://scholar.google.co.uk/citations?view_op=view_citation&hl=en&user=b632u8sAAAAJ&pagesize=100&sortby=pubdate&citation_for_view=b632u8sAAAAJ:hC7cP41nSMkC
- http://dx.doi.org/10.1002/(SICI)1096-9896(199912)189:4<627::AID-PATH479>3.0.CO;2-K
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Published on 16 Nov 2012 - 20:17 (GMT)
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Authors
- Salvador J. Diaz-Cano
- Alfredo Blanes
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