Dispacamide E and other bioactive bromopyrrole alkaloids from two Indonesian marine sponges of the genus Stylissa

S. Ebada, Sherif; Hoang Linh, Mai; Longeon, Arlette; J. De Voogd, Nicole; Durieu, Emilie; Meijer, Laurent; Bourguet-Kondracki, Marie-Lise; Nasser B. Singab, Abdel; E.G. Müller, Werner; Proksch, Peter

doi:10.6084/m9.figshare.1136010.v2

gnpl_a_947496_sm0642.docx (1.24 MB)

Dispacamide E and other bioactive bromopyrrole alkaloids from two Indonesian marine sponges of the genus Stylissa

Version 2 2014-12-20, 17:43

Version 1 2014-12-20, 17:43

journal contribution

posted on 2014-12-20, 17:43 authored by Sherif S. Ebada, Mai Hoang Linh, Arlette Longeon, Nicole J. De Voogd, Emilie Durieu, Laurent Meijer, Marie-Lise Bourguet-Kondracki, Abdel Nasser B. Singab, Werner E.G. Müller, Peter Proksch

Chemical investigation of methanolic extracts of the two Indonesian marine sponges Stylissa massa and Stylissa flabelliformis yielded 25 bromopyrrole alkaloids including 2 new metabolites. The structures of all isolated compounds were unambiguously elucidated based on extensive 1D and 2D NMR, LR-MS and HR-MS analyses. All isolated compounds were assayed for their antiproliferative and protein kinase inhibitory activities. Several of the tested compounds revealed selective activity(ies) which suggested preliminary SARs of the isolated bromopyrrole alkaloids.