Diagnosing Lassa Virus Infection by Tracking the Antiviral Response

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Sanchez Caballero, Ignacio; Y Yen, Judy; Bonilla, Gracia (2012): Diagnosing Lassa Virus Infection by Tracking the Antiviral Response. figshare.
http://dx.doi.org/10.6084/m9.figshare.97280

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Hemorrhagic fever viruses can only be diagnosed by conventional methods when the infection has spread to the blood the patient (viremia, around 8 days after infection). We set out to determine if the transcriptional dynamics of the circulating immune cells (PBMCs) in non-human primates infected with the Lassa virus could be used as an ealier indicator of infection. We identified a strong signal of infection that appear almost 5 days earlier (3dpi) than the one detected by conventional methods.

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Published on 09 Nov 2012 - 13:16 (GMT)

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