Detecting evolutionary strata on the human X chromosome: Markov Segmentation and Clustering Analysis

Share this:
Embed*
Cite this:
Wilson Sayres, Melissa; Shanker Pandey, Ravi; K Azad, Rajeev (2013): Detecting evolutionary strata on the human X chromosome: Markov Segmentation and Clustering Analysis. figshare.
http://dx.doi.org/10.6084/m9.figshare.804327

Description

In mammalian sex chromosomes, a stratum is formed on the X chromosome following the cessation of X-Y recombination. In the absence of homologous recombination, the non-recombining regions accumulate DNA elements, such as, transposable or repetitive elements, and sequences with shifts in GC content and thus the sequence composition of each strata diverges from the regions on the X that still undergo X-Y recombination. To delineate the stratum boundaries, we developed a multi-pronged strategy that applies a recursive segmentation and an agglomerative clustering algorithm within the framework of statistical hypothesis testing to identify compositionally distinct regions on the X chromosome.

Links

Comments (0)

You must be logged in to post comments.

362
views

0
shares

Published on 20 Sep 2013 - 18:01 (GMT)

Filesize is 795.23 KB

Categories

Authors

Tags

License (what's this?)

CC-BY

Export

Cite "Filename"

Place your mouse over the citation text to select it

Embed "Detecting evolutionary strata on the human X chromosome: Markov Segmentation and Clustering Analysis"

Place your mouse over the embed code to select and copy it

Claim article

You claim request was sent. I will be handled in the next 24 hours.

Close window

Feedback

We appreciate all your comments, questions, suggestions or gratitude.

Login

The username or password entered are wrong.

Reset password

Your password will be sent to your registered e-mail address.

Create account

I agree to the Terms & Conditions *