Skin-RCPath'03.pdf (26.62 MB)
Controversies in Atypical (Dysplastic) Melanocytic Nevi: Grading and Progression
presentation
posted on 2012-12-12, 20:42 authored by Salvador J. Diaz-CanoSalvador J. Diaz-Cano, E Husain- High-grade intraepidermal melanocytic lesions are mainly driven by p53 over-expression, which is dissociated from cyclin-dependent kinase inhibitors (p21WAF1 and p27Kip1) in melanoma in-situ.
- Invasion in malignant melanomas seems to be independent of p53 expression
