Cocaine self-administration in the mouse: A low- cost, chronic catheter preparation

None
Share this:
Embed*
Cite this:

Cooper, Don; Baratta, Michael; Pomrenze, Matthew; Cadle, Brian (2012): Cocaine self-administration in the mouse: A low- cost, chronic catheter preparation. figshare.

http://dx.doi.org/10.6084/m9.figshare.91521
Retrieved 16:14, Oct 01, 2014 (GMT)

Description

Intravenous drug self-administration is the most valid animal model of human addiction because it allows volitional titration of the drug in the blood based on an individual’s motivational state together with the pharmacokinetic properties of the drug. Here we describe a reliable low-cost mouse self-administration catheter assembly and protocol that that can be used to assess a variety of drugs of abuse with a variety of protocols. We describe a method for intravenous catheter fabrication that allows for efficient and long-lasting intravenous drug delivery. The intravenous catheters remained intact and patent for several weeks allowing us to establish stable maintenance of cocaine acquisition. This was followed by a dose response study in the same mice. For collaborators interested in premade catheters for research please make a request at www.neuro-cloud.net/nature-precedings/pomerenze.

Links

Comments (0)

You must be logged in to post comments.

Cite "Filename"

Place your mouse over the citation text to select it

Embed "Cocaine self-administration in the mouse: A low- cost, chronic catheter preparation"

Place your mouse over the embed code to select and copy it

Claim article

You claim request was sent. I will be handled in the next 24 hours.

Close window

Feedback

We appreciate all your comments, questions, suggestions or gratitude.

Login

The username or password entered are wrong.

Reset password

Your password will be sent to your registered e-mail address.

Create account

I agree to the Terms & Conditions *