Axinelline A, a new COX-2 inhibitor from Streptomyces axinellae SCSIO02208

Ai, Wen; Lin, Xiu-Ping; Tu, Zhengchao; Tian, Xin-Peng; Lu, Xin; Mangaladoss, Fredimoses; Zhong, Zhi-Long; Liu, Yonghong

doi:10.6084/m9.figshare.972919.v3

gnpl_a_891204_sm0385.docx (791.95 kB)

Axinelline A, a new COX-2 inhibitor from Streptomyces axinellae SCSIO02208

Version 3 2014-08-18, 13:17

Version 2 2014-08-18, 13:17

Version 1 2014-08-18, 00:00

journal contribution

posted on 2014-08-18, 13:17 authored by Wen Ai, Xiu-Ping Lin, Zhengchao Tu, Xin-Peng Tian, Xin Lu, Fredimoses Mangaladoss, Zhi-Long Zhong, Yonghong Liu

Axinelline A, a new cyclooxygenase-2 (COX-2) inhibitor, was isolated from Streptomyces axinellae SCSIO02208. The structures of compounds 1–9 were determined by analysing the NMR and MS data. The absolute configuration of 1 was determined by using optical rotation and comparing with the reported data. Compound 1 exhibited COX-2 inhibitory activity, the IC₅₀ value being 2.8 μM.