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A new lignan with hypoglycemic activity from Tadehagi triquetrum

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Version 2 2015-08-04, 14:27
Version 1 2015-08-04, 14:27
journal contribution
posted on 2015-08-04, 14:27 authored by Jiani Wu, Cai yun Zhang, Tingting Zhang, Dan Zhao, Ni An, Youbin Li, Nailiang Zhu, Shuai Wang, Feng Chen, Xiaopo Zhang

A new lignan named tadehaginosin, together with a known compound 3,4-dihydro-4-(4′-hydroxyphenyl)-5,7-dihydroxycoumarin, was isolated from the aerial part of Tadehagi triquetrum. The new structure was determined by various spectroscopic techniques (1H and 13C APT, HSQC, HMBC, 1H–1HCOSY, NOESY and HR-ESI-MS). The two isolates were evaluated for their hypoglycemic effects in vitro. Biological investigation showed that both of them possessed the capability to increase glucose consumption by HepG2 cells.

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