TY - DATA T1 - PCR-based alternative for diagnosis of immunoglobulin heavy chain gene rearrangement: principles, practice, and polemics PY - 2012/11/17 AU - Salvador J. Diaz-Cano UR - https://figshare.com/articles/journal_contribution/PCR-based_alternative_for_diagnosis_of_immunoglobulin_heavy_chain_gene_rearrangement_principles_practice_and_polemics/97678 DO - 10.6084/m9.figshare.97678.v1 L4 - https://ndownloader.figshare.com/files/224010 KW - diagnosis KW - gene rearrangement KW - lymph node KW - lymphoma KW - B-cell KW - Molecular Biology KW - Medicine KW - Hematology KW - Cell Biology KW - Cancer N2 - PCR-based detection of immunoglobulin gene rearrangements is a reliable and accurate method which can be utilized as a clinical test if appropriate quality controls are performed (internal, polyclonal and monoclonal, sensitivity and specificity controls) and strict criteria for clonal rearrangements are used to exclude false-positives and false-negatives. ER -