TY - DATA T1 - New water soluble glycosides of 11-keto-β-boswellic acid: A paradigm PY - 2017/06/19 AU - B. N. Manjunath AU - Suvarna Shenvi AU - A. Raja AU - G. Chandrasekara Reddy UR - https://tandf.figshare.com/articles/journal_contribution/New_water_soluble_glycosides_of_11-keto-_-boswellic_acid_A_paradigm/5117350 DO - 10.6084/m9.figshare.5117350 L4 - https://ndownloader.figshare.com/files/8697373 KW - Boswellia seratta KW - boswellic acids KW - glycosylation KW - bioavailability N2 - Though several glycosides of various triterpenes are known, but surprisingly no boswellic acid glycosides are reported so far. With a view to make water soluble boswellic acids, prepared glycosides of 11-keto boswellic acid for the first time. Naturally occurring boswellic acids which are anti-inflammatory agents are lipophylic in nature and thus, become a limiting factor in terms of their bioavailability. Among boswellic acids, 11-keto-β-boswellic acid is found to exhibit superior biological activity and hence successfully prepared its glucosyl and maltosyl derivatives viz., 11-keto-β-boswellic acid-24-O-β-D-glucopyranoside (9) and 11-keto-β-boswellic acid-24-O-α-D-glucopyranosyl-(1 → 4)-β-D-glucopyranoside (15) which are water soluble. Both these compounds are soluble in water to the extent of 10% (w/w) which is very significant. ER -